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KMID : 0043319950180060458
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Archives of Pharmacal Research
1995 Volume.18 No. 6 p.458 ~ p.461
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Biotransformation of Dehydroparadols by Aspergillus niger
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Lee Sang-Sup
Lee Woo-Young
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Abstract
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+To prove uniqueness of allylic alcohol formation from ketones by mammal enzymes, a metabolic pattern of dehydroparadols, non-pungent synthetic analogs of shogaol by Aspergillus niger was examined. Two biotransformation products of a dehydroparadol, 1-(4hydroxy-3-methoxyphenyl)-non-1-en-3-one were accumulated in the culture broth of A. niger. They were characterized as 1-(4-hydroxy-3-methoxyphenyl)-non-1-en-9-01-3-one and 1-(4-hydroxy-3-methoxyphenyl)-nonan-9-o1-3-one by UV, NMR and mass spectroscopic analyses. Accumulation of allylic alcohol metabolites was not observed.
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KEYWORD
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Dehydroprardol, Metabolic pattern of dehyydroparadol, Aspergillus niger, Biotranforamation
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